The death of the 70-year-old man brought the toll of the Middle East Respiratory Syndrome in the most-affected country to 69 fatalities. Four new cases of infection were registered, bringing the kingdom's total to 194, the ministry said.
It did not disclose the man's nationality.
Last week panic over the spread of MERS among medical staff in Jeddah had caused a temporary closure of an emergency room at a main hospital, prompting a visit by Health Minister Abdullah al-Rabiah aimed at reassuring an anxious public.
"The situation concerning the coronavirus is reassuring," a government statement said following the meeting.
The virus was initially concentrated in the eastern region but has now spread across other areas.
The World Health Organisation (WHO) said Friday that it had been told of 212 laboratory-confirmed cases of MERS infection worldwide, of which 88 have proved fatal.
The MERS virus is considered a deadlier but less-transmissible cousin of the SARS virus that erupted in Asia in 2003 and infected 8,273 people, nine per cent of whom died.
A recent study said the virus has been "extraordinarily common" in camels for at least 20 years, and may have been passed directly from the animals to humans.
But the Saudi health minister warned against assuming that camels were behind the virus, insisting in remarks published by Makkah daily today that "one should not jump to conclusions."
"Saudi hospitals did not deal with a single case of infection that involved contact with the animal," he said.
His statement appeared in contrast with an announcement by his ministry on November 11, which said that a camel became the first animal to test positive in "preliminary laboratory checks."
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