The announcement came as the president addressed supporters in the coastal town of Brufut on Thursday, and the comments were later broadcast on state television and repeated on his website.
"Gambia's destiny is in the hands of the Almighty Allah. As from today, Gambia is an Islamic state. We will be an Islamic state that will respect the rights of the citizens," he was quoted as saying on the presidential website.
"Christians will be given their due respect. The way of celebrating Christmas will continue," he said, adding that no one had the right to interfere with others' "way of life".
He also warned against trying to impose a dress code on women.
"I have not appointed anyone as an Islamic policeman. The way women dress is not your business," he said.
Of the remainder, eight percent are Christian and two per cent are defined as having indigenous beliefs.
Jammeh, 50, a military officer and former wrestler from a rural background, has ruled the country with an iron fist since he seized power in a coup in 1994.
Opponents say he has become increasingly paranoid, regularly reshuffling his ministers and keeping only a tiny circle of trusted allies close to him.
He cultivates the image of a practising Muslim, and is often seen holding a Koran or prayer beads, and of promoting an aura of mysticism.
The main opposition party on Saturday poured scorn on the president's unexpected proclamation of an Islamic republic, saying it had no legal basis.
"President Yahya Jammeh's pronouncement or declaration is unconstitutional, it has no constitutional basis and... It is an unlawful declaration," Ousainou Darboe, the secretary general of the main opposition United Democratic Party, told AFP.
"It is becoming ridiculous that whenever he wants to divert pubic attention from what is happening in the country, he attacks colonialism," Darboe said.
In 2013, Jammeh withdrew his country from the Commonwealth, saying it represented "an extension of colonialism".
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