Williams is famous for her portrayal of combative Arya Stark on the hit fantasy franchise.
Steven Moffat, lead writer and executive producer on the sci-fi series said Williams will challenge Doctor, reported Variety.
"It's not possible to say too much about who or what she's playing, but she is going to challenge the Doctor in very unexpected ways. This time he might just be out of his depth, and we know Maisie is going to give him exactly the right sort of hell," Moffat said.
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