The 'We're the Millers' actress was photographed on the movie set in Los Angeles, looking unrecognisable without makeup, reported Us magazine.
"It was so fabulous-so dreamy and empowering and liberating. The only time I had to sit in the makeup chair was just for the scars," Aniston, 45, said.
In the film, she plays Claire Simmons, a woman who suffers a car crash that leaves her with scars all over her body.
"It's our little love project. When I read the script, I was ready to disappear," she added.