The gunman also died in the incident at Reynolds High School in Troutdale in the northwestern US state, said the local police chief.
"A gunman entered the high school this morning, shot one student. Unfortunately, that student has died," said police chief Scott Anderson in the city just east of Portland.
"The gunman was located and the gunman is also deceased ... The situation is contained," he added.
Large numbers of armed police scambled to lock down the school after reports of shots fired around 8:00 am.
There were no immediate reports of other casualties, after children could be seen in live TV images filing out with their hands on their heads.
Some 60 law enforcement officers and 19 medical personnel descended on the school, according to local KOIN television.
The shooting is the latest in a spate of such incidents over the past few weeks in the former Wild West region of the United States.
On May 23, a student with mental problems, the son of a Hollywood director, went on a gun rampage at a college campus in Santa Barbara, north of Los Angeles, killing six people and then himself.
On Sunday, a couple with possible links to anti-government militia shot dead two police officers execution-style in a Las Vegas pizza restaurant, before killing another civilian nearby and then themselves.
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