Harsh reviews have poured in from professional film connoisseurs and regular crowds alike despite promotional claims that the movie features the biggest roster of stars "ever assembled" in one film, reported Daily Mail.
Due to that star-studded cast, which also includes actors Hugh Jackman, Emma Stone, Kate Winslet, Gerard Butler and Richard Gere, many had expected 'Movie 43' to be a guaranteed hit.
Instead, the USD 6 million production opened in seventh place this weekend bringing in a relatively dismal USD 5 million in the US and marking one of the worst wide-release openings for many of the actors featured.
Critic Peter Howell of the Toronto Star called it the "worst film ever" saying it was the "biggest waste of talent in cinema history".
Critic Richard Roeper of the Chicago Sun Times said he did not "see a redeeming molecule" throughout the film.
Farrelly quickly defended his work, tweeting, "To the critics: Movie 43 is not the end of the world. It's just a USD 6-million movie where we tried to do something different. Now back off."
"To the critics: You always complain that Hollywood never gives you new stuff, and then when you get it, you flip out. Lighten up," he added one minute later.
The movie follows 12 distinct story lines, each created by a different director and featuring different actors.
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