Speaking to a UN climate conference in Morocco, Hollande praised US President Barack Obama for his role in getting the landmark pact adopted in the French capital last year.
"The United States, the most powerful economy in the world, the second-largest emitter of greenhouse gases, must respect the commitments that were made," he said. "It's not simply their duty, it's in their interest."
"The agreement was historic," Hollande said. "But what we must say here is that this agreement is irreversible."
Earlier, UN Secretary-General Ban Ki-moon said he hopes Trump will shift his course on global warming and "understand the seriousness and urgency" of addressing the problem.
"As president of the United States, I'm sure that he will understand this, he will listen and he will evaluate his campaign remarks," Ban told reporters in Marrakech.
Ban called international climate action "unstoppable" and said that no country, "however resourceful or powerful," is immune from the impacts of global warming.
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