Three people, including the gunman, were killed in the incident that left seven others injured.
Schumer, who stars in the film, was one of the first to react.
"My heart is broken and all my thoughts and prayers are with everyone in Louisiana," the comedienne tweeted.
The shooting happened during a screening at the Grand 16 Theatre of the comedy, which also features Bill Hader and LeBron James. The movie was directed by Judd Apatow, who is yet to comment.
"So sad to hear about the shooting. Prayers go to the victims and their families," boxer Sugar Ray Leonard wrote on Twitter.
Trump also offered his condolences. "Thoughts & prayers with everyone in Lafayette, Louisiana this evening," he wrote.
Green wrote on his Twitter page, "Came back to the hotel and saw the devastating news about the shooting in Lafayette. Sending my thoughts and prayers to all involved."
"Another movie theater shooting. What is the appropriate amount of time to wait before we start discussing gun control again. Oh, never?" American comedian Michael Ian Black tweeted.
Timonthy Simons wrote, "We have put the rights of people to carry guns ahead of the rights of people (and children) to live. We have the country we deserve.
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