Zakir, 40, was killed last night by four armed assailants who came on two motorcycles while he was having dinner at a restaurant in Sector 11 of New Karachi.
A journalist, Rao Khalid who was with Zaki and a bystander Aslam were critically wounded in the attack.
The assailants attacked Zaki and Khalid with bullets and Aslam a bystander was caught in the firing, Senior Superintendent of Police Muqaddas Haider said.
He had condemned extremism in all forms and came into limelight when he led a campaign against Lal Masjid cleric, Maulana Abdul Aziz for inciting hatred against Shia Muslims. He and other campaigners built up pressure and got a case registered against Aziz.
Zaki's assassination came on the same day when Karachi police announced that they had arrested a prime suspect in the murder of social activist Parveen Rehman who was killed in May 2013.
Last year in September, another prominent social activist and rights campaigner Sabeen Mahmud was also killed in the defence area in Karachi while returning from her office. Her assailants are yet to be nabbed by the police.
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