The rebel withdrawal began a month to the day after President Bashar al-Assad's forces launched a new offensive to recapture Aleppo and will hand the regime its biggest victory in more than five years of civil war.
A revived agreement on a ceasefire and the evacuations was announced today, after an initial plan for civilians and fighters to leave rebel-held parts of east Aleppo collapsed the previous day amid renewed clashes.
The evacuation began with a convoy of ambulances and buses crossing into a government-held district in southern Aleppo around 2:30 pm (local time).
The convoy arrived just over an hour later in opposition territory west of the city, a doctor at the scene said.
"Vehicles carrying the wounded have arrived, and the wounded will be transferred to... Nearby hospitals for treatment," said Ahmad al-Dbis, who heads a unit of doctors and other volunteers coordinating the evacuation of wounded people.
He spoke to AFP from the transit point near opposition-controlled Khan al-Aassal, about five kilometres (three miles) west of Aleppo city.
An AFP correspondent there saw people piling onto the green buses, filling seats and even sitting on the floor, with some worried that there would not be another chance to evacuate.
Many were in tears and some hesitated to board, afraid they would end up in the hands of regime forces.
On the dusty window of one of the buses someone had written "One day we will return".
Each bus carried a member of the Syrian Red Crescent dressed in the organisation's red uniform, riding at the front next to the driver.
Once the first convoy arrives safely "it will return and collect more people for a second journey and continue like that. We will go today for as long as conditions allow," she told AFP.
Syrian state television reported that at least 4,000 rebels and their families would be evacuated under the plan.
It said preparations were underway for a second convoy to leave rebel-held territory.
A first evacuation expected to take place on Wednesday morning fell apart, with artillery exchanges and resumed air strikes rocking the city until the early hours today.
The defence ministry in Moscow said that Syrian authorities had guaranteed the safety of the rebels leaving the city.
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