With temperatures above 40 Celsius (104 Fahrenheit) for the second straight day, Dodig became the latest casualty when he retired with severe cramp after four sets against Bosnia's Damir Dzumhur.
"I was thinking I could maybe even die here," said Dodig, calling for an afternoon break in play. "It's not acceptable to play in these conditions," he added, according to reports.
Dodig's complaints follow dismal scenes on Tuesday, when Canada's Frank Dancevic blacked out, China's Peng Shuai vomited in the extreme heat and a ball boy collapsed.
Dodig became the tournament's 10th withdrawal or retirement, after a Grand Slam record-equalling nine players pulled out during the first round.
Although most of the players cited injuries, Dutch player Robin Haase was another victim of cramp, which is associated with hot conditions.
Dancevic, who felt dizzy and then fainted during his loss to Benoit Paire, said it was easier for players to suffer injuries when affected by the heat.
"I think when you're running around on court quite dizzy, you're more prone to getting injured also," Dancevic said. "You can't play the way you want to play, you can't move the way you want to.
Tournament organisers said no players needed medical help on Wednesday, adding that conditions were not dangerous enough to warrant halting play.
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