The International Atomic Energy Agency "remains committed to working constructively with Iran, under the country's new government, to resolve outstanding issues by diplomatic means," Yukiya Amano told a meeting of the IAEA's board of governors.
He added however: "Given the nature and extent of credible information available to the agency about possible military dimensions to Iran's nuclear programme, it remains essential and urgent for Iran to engage with us on the substance of these concerns."
It is because of this that the UN Security Council has passed six resolutions since 2006 -- four with sanctions attached -- calling for Tehran to suspend key parts of its nuclear work.
Denying it wants nuclear weapons, Iran has instead defiantly continued to expand its programme, most notably in the enrichment of uranium, which in highly purified form could be used in a bomb.
The United States and Israel, the Middle East's sole if undeclared country with nuclear weapons, have refused to rule out military means to stop Tehran's nuclear drive.
Conciliatory-sounding noises from Hassan Rowhani since his election as president in June, replacing the more hardline Mahmoud Ahmadinejad, has however created some hope.
Himself a former nuclear negotiator, Rowhani has handed responsibility for future talks to the foreign ministry under the US-educated moderate Mohammad Javad Zarif.
A new round of talks between Iran and the IAEA is set for September 27, and a meeting with the five permanent members of the UN Security Council plus Germany (the P5+1 or E3+3), the first since April, is expected soon.
The two will meet during the UN General Assembly later this month.
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