Mathew Martoma, 39, has pleaded not guilty to one count of conspiracy to commit securities fraud and two counts of securities fraud.
The trial is scheduled to begin today in the federal district court in Lower Manhattan, with 80 potential jurors filling out questionnaires to determine whether they can be fair. A jury of 12 with four alternates will hear the case.
Manhattan's India-born top federal prosecutor Preet Bharara, who had brought the case against Martoma, described the charges as "the most lucrative insider trading scheme ever charged".
Martoma was arrested in November 2012 from his home in Boca Raton, Florida and has been freed on a USD five million bail.
A Stanford graduate, Martoma joined the hedge fund company SAC Capital Advisors in 2006 and had worked with the firm's affiliate CR Intrinsic Investors.
In a yesterday's ruling, presiding judge Paul Gardephe said prosecutors cannot introduce evidence that Martoma had fainted when FBI agents approached him in November 2011 on the lawn of his USD 1.9 million Boca Raton home, telling him that they wanted to talk "about insider trading" at SAC.
The judge said it would not be appropriate to assume Martoma fainted because he knew he was guilty.
Federal prosecutors have accused Martoma of using material, non-public information that he received from a doctor in 2008 on the clinical trial of an Alzheimer's disease drug to make profits and avoid losses for SAC in an amount totaling approximately USD 276 million.
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