The World Anti-Doping Agency (WADA) has already launched an investigation into suggestions that urine sample bottles manufactured by Swiss company Berlinger could be opened manually.
WADA said it had been alerted by an accredited laboratory in Cologne that the bottles could be opened after being frozen.
Berlinger told AFP that in tests, it had been unable to replicate the alleged problem and that any difficulties stemmed from the fact that the bottles had not been properly closed after use.
The IOC said it was "very concerned about this issue".
"From the moment we learned about it, we immediately turned to WADA and asked them to ensure that the anti-doping tests in Pyeongchang can be conducted in a credible and reliable way," it said in a statement.
The Olympics open in Pyeongchang, South Korea, on February 9.
In the 2014 Sochi Olympics doping scandal detailed in a report by Canadian lawyer Richard McLaren, investigators discovered that Russian staff involved had developed a way of opening "tamper-proof" sample bottles undetected.
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