Hassan Rouhani's comments today come as President Donald Trump appears to be stepping back from his campaign pledge to rip up the deal, instead aiming to take other measures against Iran.
Addressing students at Tehran University, Rouhani says: "We have achieved benefits that are irreversible. Nobody can roll them back, neither Trump, nor 10 other Trumps."
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Trump is expected to take new action against Iran's Revolutionary Guard and the Iranian backed Shiite militant group Hezbollah.
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