In a letter to the president on Wednesday, Supreme Leader Khamenei for the first time endorsed the accord Tehran struck in July with world powers, but warned that Iran must guard against weakness in carrying out its provisions.
The agreement with the five permanent members of the UN Security Council plus Germany will see a raft of trade sanctions against Iran lifted in return for curbs lasting up to 15 years on its atomic activities.
"The Islamic Republic of Iran's government will act to thoroughly implement the JCPOA, while observing his Honourable considerations and the ratifications of the Supreme National Security Council," the president said.
Khamenei said he approved the decision of the country's top security committee, the SNSC, to implement the agreement.
"The other sides' actions to fulfil their commitments will be vigilantly monitored and a proper decision will be made by the SNSC," he assured, in case any of the six powers -- Britain, China, France, Germany, Russia and the United States -- breached the accord.
However, according to the leader's order, Iran is holding back on some of its commitments until the UN nuclear watchdog announces that Tehran's past and current atomic activities are clean.
The International Atomic Energy Agency has until December 15 to issue its report on Iran's nuclear programme.
Rouhani said Khamenei's "confirmation, along with the conditions you set... Would open a new chapter" in Iran's path to progress.
In his letter, Khamenei warned the deal had "many ambiguities and structural weak points" which must be closely monitored.
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