The Syrian Observatory for Human Rights also reported that 22 civilians were killed in air strikes on IS-held areas in northern Syria.
IS launched simultaneous attacks near the Mahr and Shaar oil and gas fields and elsewhere in the desert in eastern Homs, said the Britain-based monitoring group, which earlier gave a death toll of 26 among pro-regime forces.
"IS was able to take control of seven checkpoints and other positions held by government forces, who were forced to withdraw amid fierce clashes," Observatory director Rami Abdel Rahman said.
It now regularly attacks isolated army positions in the area, as well as oilfields under government control.
Some northern parts of Homs are held by various rebel groups, but the government holds the rest of the province.
Further north, 11 civilians were killed in a strike believed to have been carried out by the US-led coalition fighting IS in the village of Al-Mashrifa in Raqa province yesterday night.
Another three people were killed in strikes, also believed to have been carried out by coalition aircraft, on the village of Al-Abarah in Raqa, the monitor said.
The US-led coalition says it investigates credible reports of civilian casualties in its strikes and has acknowledged a handful of civilian deaths in Syria since it began raids there in September 2014.
Raqa is home to IS's de facto Syrian capital, Raqa, though a Kurdish-Arab alliance backed by the US-led coalition launched an offensive to recapture the city and surrounding province last month.
Elsewhere, the Observatory said eight people were killed in strikes on the IS-held village of Bzaa in northeast Aleppo today morning.
Turkey began an unprecedented operation inside northern Syria dubbed "Euphrates Shield" on August 22, saying it was targeting both IS but also Kurdish militants that have battled the jihadist group.
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