The reclusive leader of IS, who has only appeared in public once, also vowed to continue fighting and lavished praise on his jihadis for their valour in the battlefield despite the militants' loss of the northern Iraqi city of Mosul in July.
The recording was released on Thursday by the IS-run al- Furqan outlet, which has in the past released messages from al-Baghdadi and other top figures of the extremist group. The voice in the over 46-minute-long audio sounded much like previous recordings of al-Baghdadi. His last previous purported message was released in November, also in an audio recording.
Russian officials said in June there was a "high probability" that al-Baghdadi had died in a Russian airstrike on the outskirts of the Syrian city of Raqqa, the group's de facto capital. US officials later said they believed he was still alive.
Al-Baghdadi's whereabouts are unknown but he is believed to be in IS' dwindling territory in eastern Syria. The IS-held cities of Raqqa and Deir el-Zour are under siege and likely too dangerous for him to hide in.
"You soldiers of Islam, supporters of the caliphate everywhere, step up your attacks and include the media centers of the infidels and the headquarters of their ideological war among your targets," he said in the recording, apparently alluding to Western news outlets and research centers.
"Don't you dare allow the Crusaders and the apostates to enjoy a good and comfortable life at home while your brothers are enduring killings, shelling and destruction," added al- Baghdadi, who reminded his followers of the rewards of martyrdom, including "72 wives" from among the maidens of paradise.
"In Mosul, they defiantly stood firm on a land ruled by God's laws against the infidels and nations of the cross ... only leaving it over their skulls and dead bodies after nearly a year of fighting," he said.
"The sons of Islam will willingly continue to sacrifice their blood and bodies for the sake of their creator," he defiantly declared.
In the recording, he also consoled IS fighters over the number of major military setbacks suffered in recent months in both Iraq and Syria, but also made a passionate plea for them to rise up and never surrender.
In Yemen, Iranian-backed Shiite rebels are fighting forces loyal to the internationally recognised government, which is backed by a Saudi-led coalition.
Addressing Syria's Sunni Muslim majority, he warned them against the "cunning" of the minority Alawites, an offshoot Shiite sect from which President Bashar Assad hails, as well as the designs of Turkey and Assad's allies Russia and Iran.
"What have you gained from the conferences of humiliation and the crumbs of supporters except appeasing the Alawites and surrendering your homes?" said al-Baghdadi, adding that Syria's government forces, their allies and other forces fighting IS, would "not last an hour" without the air cover provided by the Russia or the US-led coalition.
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