The Syrian Observatory for Human Rights said IS had dispatched a small group of jihadists -- including one driving an explosives-laden car -- into villages southeast of their bastion of Manbij.
The villages had been seized in recent weeks by the US-backed Syrian Democratic Forces in their push for Manbij.
"IS is trying to defend Manbij by sending fighters from outside the town to attack the SDF in these villages," said Rami Abdel Rahman, the director of the Britain-based Observatory.
The head of the Observatory, which relies on a vast network of sources on the ground for its information, did not have an immediate toll from the villages.
The US-led coalition backing the SDF carried out a barrage of air strikes today to defend the villages, said Abdel Rahman.
At least four SDF fighters were killed in the clashes and many more were wounded.
The SDF -- a Kurdish-Arab alliance with air support from the US-led coalition -- encircled Manbij nearly 10 days ago.
But since then, they have been slowed by almost daily suicide bombings as IS puts up a fight for the town.
IS is also mounting a fierce defence of Tabqa, which has been under attack by Russia-backed regime forces since early June.
Today, the Observatory said, a failed IS counterattack against regime fighters southwest of Tabqa killed at least 14 jihadists and six government loyalists.
"IS dispatched 300 fighters from Raqa to Tabqa to help defend the town," Abdel Rahman said.
Syria's civil war began with the brutal repression of anti-government demonstrations in 2011 and has now killed more than 280,000 people and displaced millions.
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