The 32-year-old actor said he went for a major weight loss for his role as a struggling, freelance video news reporter in the film, reported People magazine.
"I can only approach things from a mental place. Like I'm playing a character who's hungry, figuratively and literally, who's driven in ways to do things and succeed at any cost," Gyllenhaal said.
"And I think that defines a generation in a lot of way so I wanted to get their mentally and then have it transform me physically, because I am not one to rely on science as much as I am on just sort of instinct. That's sort of the character," he added.
'Nightcrawler' to be directed by Dan Gilroy, also stars Bill Paxton and Rene Russo. It is set to release next year.
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