Tempers were frayed a day after the twin bombings that tore through crowds of Shia Hazara protesters, as many anxiously searched hospitals and morgues, looking among the mutilated bodies for missing relatives.
The attack in the majority Sunni country highlighted the risk of sectarian disharmony in a nation that has largely avoided the bloody strife between Sunnis and Shias across much of the Muslim world.
The bombings occurred as thousands of Hazara protesters had gathered to demand that a multi-million-dollar power line pass through their electricity-starved province of Bamiyan, one of the most deprived areas of Afghanistan.
Ghani renamed the site of the attack as "Martyr's Square". It remained littered with scorched metal, charred flesh and forlorn personal items including shoes, ID cards and protest banners with messages such as "Don't eliminate us".
The wounded overwhelmed city hospitals, with reports of blood shortages and urgent appeals for donors swirling on social media.
IS, which controls territory across Syria and Iraq, claimed the bombings in a statement carried by its affiliated Amaq news agency, calling it an attack on a "gathering of Shiites".
The devastating attack in the capital represents a major escalation for IS, which so far has largely been confined to the eastern province of Nangarhar where they are known for brutality including beheadings.
NATO this month claimed that the group's influence was waning as it steadily lost territory, with their fighters largely confined to two or three districts in the province from around nine in January.
"There is no doubt that IS is under intense pressure in Nangarhar, and they are desperate to reassert themselves with attacks such as the one in Kabul," analyst Ahmad Saeedi told AFP.
The Taliban, who are in the middle of their annual summer offensive and are more powerful than IS, strongly denied any involvement in Saturday's attack.
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