The train travelling from Azamgarh to Delhi collided with a dumper at around 2:50 am between Pata and Achhalda railway stations, a spokesperson for the North Central Railway (NCR) said.
One bogie of the train overturned due to impact of collision and some compartments jumped the rails between Acchalda and Pata railway stations after crossing Kanpur, Superintendent of Police Auraiya Sanjeev Tyagi said.
At least 21 passengers were injured and have been rushed to the hospital, a spokesperson of NCR said.
Railway Minister Suresh Prabhu tweeted, "A dumper hit the locomotive of the Kaifiyat Express,resulting in derailment. Some passengers have received injuries and have been shifted to nearby hospitals".
He said that he was personally monitoring the situation and had directed senior officials to reach the site immediately.
Kaifiyat Express travels between Azamgarh in Uttar Pradesh and Delhi and the collision has impacted the train operations on the Delhi-Howrah route.
Five trains including Howrah-New Delhi Rajdhani have been diverted and seven trains including Kanpur-New Delhi Shatabdi express have been cancelled. Since both UP and DOWN lines are blocked, around 40 local trains were also being diverted.
On receiving information about the mishap, senior officials rushed to the accident site which comes under Acchalda police station, around 180 kilometres from Lucknow.
Additional forces and ambulance were rushed to the spot from Auraiya, Etawah and Kannauj, while NDRF team was dispatched from Lucknow to provide support to the victims. A medical train and a relief train have been dispatched from Allahabad to the accident site.
A spokesman for NCR said rescue operations have been concluded and all injured were sent to hospitals nearby.
General Manager, NCR, M C Chauhan and the Divisional Regional Manager have rushed to the spot.
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