Pacers Aswin Crist and T Natarajan ran through Karnataka's first innings, sharing nine wickets between them.
Nair (14) and Rahul (4), who belted a scintillating 303 not out and 199 respectively in the just-concluded home Test series against England, failed along with the rest of their teammates.
At the close of Day One, Tamil Nadu were sitting pretty with 111 for four, gaining a lead of 23 runs over Karnataka. Dinesh Karthik and Abhinav Mukund were batting on 31 and 3, respectively.
Karnataka lost their next four wickets after adding 57 runs on the board.
Kaunain Abbas, who was the second batsman to walk back to pavilion, struggled to open an account even after he had faced 24 balls. He became the first victim of Crist after he gave a catch to Vijay Shankar, when the score was 10 in ninth over.
In the next 10 overs, Karnataka lost R Samarth (11), A Mithun (6) and Manish Pandey (28), who was the highest-scorer for the team.
For Tamil Nadu, Crist was the top bowler, who bagged six wickets for 31 runs in 13.1 overs and Natarajan ended with three for 18 in 9 overs. K Vignesh also picked up a wicket for 32 runs in 11 overs.
In reply, the script of Tamil Nadu innings was no different from Karnataka as they also lost three wickets for 33 runs, with their top-order -- L Suryaprakash (15), B Indrajith (1) and Kaushik Gandhi (15) -- marched back to the pavillion.
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