Kerry said failure to pass the Trans Pacific Partnership would not only hurt American business but embolden rivals and enemies like China and North Korea as well as cast doubt among US allies in the region over American resolve.
Kerry said rejection would amount to "a unilateral ceding of American influence and power and will have grave consequences," notably in the Asia Pacific.
"Either the United States of America is an Asia-Pacific power or we are not and the 'not' carries with it serious consequences," he said.
"The TPP will reinforce our status as a world leader," Kerry said. "We can't sit on the sidelines and expect to send a credible message to partners or potential partners. They would be affected by us turning our back on an agreement."
The agreement would lower or eliminate thousands of tariffs and enshrine quality and worker rights standards among its signatories.
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