Russia and the United States are nominally co-chairs of international efforts to bring Bashar al-Assad's regime to the negotiating table with armed opposition groups.
But ferocious bloodshed continues in defiance of a series of failed ceasefires, and the odd couple heading the peace effort appear increasingly at odds over the way forward.
Kerry told diners at a delayed Eid al-Fitr supper yesterday that he would meet Putin "to see if we can somehow advance this in the important ways that people want us to."
But, as Kerry's spokesman John Kirby said of his boss to reporters earlier: "I'd say he's extremely frustrated, and we want to see real change in what's been going on.
"I believe he meant every molecule of what he said when he said that his patience was growing thin," Kirby said.
In Washington, many observers have criticized Kerry's outreach to Russia on Syria, arguing he has been strung along by a Putin seeking only to protect his client Assad.
Hopes for the existing peace process rest on the UN-backed blueprint sketched out by the 22-nation, US and Russian-led International Syria Support Group (ISSG).
Under this road map, signed by both Syria's ally Iran and Assad's pro-rebel foe Saudi Arabia, a nationwide ceasefire will precede Geneva-based talks on "political transition."
Substantial political talks were once supposed to start on August 1, although Kerry has sought to underline that this is a "target" and not a "drop dead date" nor deadline.
Kirby said talk of the August 1 target date "underscores the importance of the secretary's trip to Moscow and the conversations that he intends to have there."
But he added "clearly, we are not ignorant to the fact that achieving some sort of groundbreaking political development in two weeks is not likely."
Previously, Kerry has suggested that if there is no breakthrough by the target date then Washington might resort to an undefined "Plan B" to deal with Assad.
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