"Intelligence reports indicated that the group was in the final stages of plans to execute major attacks against western targets and potentially the US homeland," Lieutenant General William Mayville, director of operations for the Joint Chiefs of Staff, told reporters.
The strikes against the Khorasan group early today were separate from a wave of bombing raids led by the United States and backed by several Arab countries that targeted the Islamic State group.
US Central Command, which oversees American forces in the Middle East, had announced that US warplanes carried out eight air strikes against Khorasan group targets west of Aleppo.
Mayville said more than 40 Tomahawk missiles were launched, and that "the majority of the Tomahawk strikes were against Khorasan."
Speaking of the broader campaign that included Arab states, Pentagon spokesman Rear Admiral John Kirby said "our initial indication is that these strikes were very successful."
And he suggested that more US action in Syria was forthcoming.
The overnight operation was the first in which the US military's new F-22 Raptor strike fighter was used in combat.
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