Moving gingerly on the lush surface, Kvitova subsided to a 6-4 4-6 6-3 second round loss to Jelena Ostapenko, the world number 38. Erasing a 0-2 deficit in the decider visibly encouraged the 19-year-old Latvian, who pressed harder, hit flatter, and often played the big points better.
"It was difficult to put the pressure on her," said Kvitova, who played with her right thigh strapped.
Neither player was helped by a slightly late start and a 40-minute interruption in the middle of the match, both caused by incessant showers which have blighted the tournament for four days.
Perhaps unsurprisingly it was the younger player who proved more resilient in dealing with it all.
She followed it with a poor game, failing to land her first serve frequently enough and then playing an even more disappointingly in the seventh game, delivering a double fault and dropping her serve to love.
She earned a break back point in the following game but was denied by a brilliant forehand from Ostapenko and after that the match ended swiftly.
"I'd beaten her before," said Ostapenko, referring to a victory on hard courts in Doha in the first week of the year.
She next plays Madison Keys, the top 20 American for a place in the semi-finals. Kvitova was followed to the exit door by Caroline Wozniacki, the former world number one, was who beaten 6-4 6-7 (5/7) 6-2 by Yanina Wickmayer, ranked down at 49 but a former finalist in Birmingham.
Wozniacki has also been struggling with injuries in recent weeks, and had moments when she appeared concerned not to aggravate them in a match that was interrupted three times by the weather.
Two other seeds, Angelique Kerber, the Australian Open champion, and Carla Suarez Navarro were also struggling when rain ended play early for the fourth day in a row.
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