Manchester City will face Liverpool in a mouthwatering all-English Champions League quarter-final while Juventus have a chance to gain revenge on holders Real Madrid in a repeat of last year's final.
Surprise qualifiers Sevilla take on five-time European champions Bayern Munich while Lionel Messi's Barcelona were paired with AS Roma in the draw made in Nyon on Friday.
Jurgen Klopp's Liverpool side will host Pep Guardiola's City at Anfield for the first leg, either on April 3 or April 4, as the sides play each other for the first time in Europe.
It will also be the first meeting of two English clubs in the last eight of the Champions League since Manchester United overcame Chelsea at that stage in the 2010-2011 season on their way to the final.
City's director of football Txiki Begiristain said: "We know each other very well, they are a very offensive team, the truth is it is going to be a great couple of games."
Real Madrid director Emilio Butragueno said it would be a "very special match"
"Juventus played against Tottenham, which had extraordinary results and was superior, and yet, despite the difficulties, came through. They have a competitor's mentality."
Roma's sporting director Monchi joked: "You can't say we were very lucky with this draw."
"So we'll be very focused when we go over there (for the first leg) and then we'll do the business at home."
Sevilla's sporting director Oscar Arias said: "This is very difficult. We are facing one of the historic clubs of European football, a great club in this competition. But we are up for it."
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