Jose Mourinho faces a quandary as he prepares Manchester United for a trip to Premier League leaders Liverpool while Manchester City will be keen to show that last week's Chelsea defeat was just a blip.
United have an impressive recent record against Liverpool, unbeaten in eight league games, but away fans will travel with a sense of trepidation to Anfield.
Unai Emery takes his Arsenal side, unbeaten in 21 matches in all competitions, to face struggling Southampton while Chelsea also travel to the south coast to take on Brighton.
Manchester City host seventh-placed Everton while Tottenham, fresh from reaching the Champions League knockout phase, face Burnley at Wembley.
AFP Sports picks out some of the main talking points ahead of the weekend fixtures in the Premier League.
Can Mourinho end Liverpool's unbeaten run?
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Jesus firing blanks
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Arsenal's defensive crisis
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Pochettino's rising stock
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