The 40-year-old centrist is expected to lay out his demands for Britain, outlined by ministers in previous days, as well as defend his government's own controversial proposals to stem the flow of people into France.
At stake is a 2003 agreement between Britain and France which effectively moved the UK border onto French territory, meaning the area around Calais has become a bottleneck where migrants heading for Britain wait.
"It's in their interests that things go well," Collomb told the France 2 television channel today ahead of a meeting between Macron and British Prime Minister Theresa May on Thursday in London.
Referring to the importance of Calais for the British economy, which faces uncertainty ahead of the country's exit from the European Union, Collomb added that "a quarter of their trade transits through Calais."
Hundreds of migrants are still massed in the area, over a year after the former Socialist government demolished the Jungle, a squalid makeshift camp in Calais, and moved its more than 7,000 occupants to shelters nationwide.
As a candidate ahead of this election in May, Macron had consistently said that he intended to renegotiate the 2003 border agreement with Britain, known as the Le Touquet accord.
France received a record 100,000 asylum claims last year, making it one of Europe's top destinations.
Macron has promised to speed up waiting times for asylum applications while also stepping up expulsions of those who remain in France after being turned down for refugee status -- an approach he touts as mixing "efficiency" and "humanity".
NGOs, trade unions and left-wing parties take a different view, often accusing him of wielding an iron fist in a velvet glove.
Two NGOs on the frontlines of the crisis in Calais refused an invitation to meet with Macron today due to repressive measures used by the French police around Calais to stop migrants setting up camps there.
Francois Guennoc of the Auberge des Migrants charity said he did not want to act "merely as an alibi for a strategy that is already well established".
Auberge des Migrants and another Catholic association filed a criminal complaint yesterday over security forces allegedly destroying the belongings of migrants in the area.
Natacha Bouchart, the right-wing mayor of Calais, told BFM television yesterday that the local population was "tired" of the situation and expected a lot from the president's visit.
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