The fire engulfed the Rongjiyan Agricultural Wholesale Market in Gongming New District of Shenzhen bordering Hong Kong at about 1 am local time, state broadcaster CCTV reported.
It took nearly two hours for 145 fire fighters and 29 fire engines to put out the fire. It damaged an area of 1,000 square meters, the report said.
As per last reports, fire fighters were still clearing the ember and searching for survivors in the debris.
Earlier in 2000, 309 persons were killed in a shopping centre blaze in central China's Henan province.
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