Aziz is pushing to abolish the country's Senate and several other state bodies and to make a small alteration to the national flag, measures that have galvanised a boycott movement hoping to sap the vote's credibility by forcing a low turnout.
Polling stations opened at 7:00 am and were due to close at 7:00 pm in the conservative west African nation, where violent clashes have broken out after the authorities banned several rallies planned by opponents of the changes.
While Aziz, his supporters and several opposition parties are seeking a "Yes" vote, one moderate opposition party is seeking a "No", while the remaining parties have joined civil society groups to call for a total boycott for amendments they consider unconstitutional.
Jemil Ould Mansour, head of the Islamic Tewassoul party spearheading the movement against the vote, said the country's leaders had fixed "the electoral roll and voting materials to prepare fraud on a massive scale," and warned of violence.
The boycott movement draws broad political support from figures as diverse as religious conservatives and anti-slavery activists.
They have held several protests attracting thousands of supporters, but have also been prevented from demonstrating by the security forces, who on Thursday shut down several planned rallies close to the capital with tear gas and baton rounds.
The UN Human Rights Office said Thursday that "protest leaders were reportedly beaten up and a number of them were arrested" during campaign rallies in the last few weeks, urging the government "take all necessary measures to ensure free, transparent and credible elections".
The proposal to modify the constitution, in force since 1991, was approved by lawmakers in the lower house but rejected by 33 out of 56 senators in March, leading Aziz to call the referendum to push through the changes.
The most contentious measure remains the abolition of the Senate and its replacement with elected regional councils, and Senators have held a sit-in this week and demanded apologies from Aziz for accusing them of corruption.
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