Jose Mourinho will inevitably be the centre of attention as he takes charge of Tottenham for the first time this weekend while Manchester City look to get their Premier League title challenge back on track against Chelsea.
The former Chelsea and Manchester United manager has been charged with rescuing Spurs' season after this week's sacking of Mauricio Pochettino, with the club desperate to claw their way back into the top four.
At the top of the table, runaway leaders Liverpool have a winnable-looking fixture away to Crystal Palace but the chasing pack cannot afford to allow the gap to widen further.
City, licking their wounds after their 3-1 defeat by Liverpool earlier this month, host Frank Lampard's Chelsea, who are one point above them in the table, eight points behind Jurgen Klopp's side.
Leicester, in second place, ahead of Chelsea on goal difference, travel to England's south coast to take on Brighton.
AFP Sport picks out some of the talking points ahead of the weekend's matches:
The Mourinho factor
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"My gift is this squad, the squad is very, very good."
Liverpool's mental strength
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"I think everybody sees how talented the squad is, how many good players we've got in the team, but mentality is huge in football."
Lampard returns
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Leicester riding high
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