Last month's raid in the northern city in Kunduz killed at least 30 people, sparking an avalanche of global condemnation and forcing the French-founded charity to close the trauma centre.
"The view from inside the hospital is that this attack was conducted with a purpose to kill and destroy," MSF general director Christopher Stokes said in Kabul while releasing an internal review of the strike.
"But we don't know why. We don't have the view from the cockpit, nor what happened within the US and Afghan military chains of command."
Three separate investigations -- led by the US, NATO and Afghan officials -- are looking into the strike, but MSF has labelled the incident a war crime and demanded an independent probe by an international fact-finding commission.
US President Barack Obama has admitted the strike was a mistake, but the Pentagon has offered shifting explanations for what exactly went wrong.
MSF said the raid by an American AC-130 gunship, which occurred after the Taliban's brief but bloody capture of Kunduz, lasted around an hour despite repeated messages to military officials in Kabul and Washington that were listed in the report in chilling detail.
"At 2.59 am an SMS reply was received by MSF in Kabul from NATO saying 'I'll do my best, praying for you all.'"
Afghan officials have repeatedly said that Taliban fighters had sought shelter in the hospital, in a tacit justification for the bombing that drew widespread condemnation.
"Some public reports are circulating that the attack on our hospital could be justified because we were treating Taliban," said Stokes.
