In an exit-memo on accomplishments of the State Department during the Obama Administration, Kerry said a number of areas of disagreements existed between the US and China.
"We have areas of vigorous disagreement, including on cybersecurity, human rights, and disputes in the East and South China Seas. In the years ahead, there is perhaps no more important issue on the US-China agenda than North Korea's increasingly destabilising and provocative behaviour," he said.
Kerry also said the two countries have worked together to increase stability in states like Afghanistan, confront global health epidemics and address development challenges.
In a separate Defense Department's exit-memo, Defense Secretary Ashton Carter said tensions in the South China Sea must be managed as must the consequences of North Korea's continued provocative actions.
Carter said the Obama Administration had regularised military-to-military contacts with China at all levels, concluding two risk reduction confidence-building measures in an effort to improve transparency and reduce the risk of unintended incidents.
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"America is a Pacific nation, and the future of the Asia-Pacific region is closely intertwined with our own," Carter said, adding that the next Administration should continue to pursue additional force posture opportunities, forge closer partnerships with and among countries across the region, and look to protect and strengthen existing alliances and partnerships.
Kerry said since his first day in office, Obama has taken the fight directly to al-Qaeda and its affiliates, never hesitating to use force when necessary to protect the American people.
"Obama made it a top priority from day one to go after Osama bin Laden and bring him to justice. Since 2009, we have decimated al-Qaeda core's senior leadership in Afghanistan and Pakistan, including bin Laden, and we've targeted al-Qaeda's affiliates in Yemen, Somalia, and elsewhere," he said.
Kerry said the ISIS has dramatically undermined stability not just in the Middle East but in other regions as well, and it poses a threat to international peace and security, including a direct threat to many of its key partners and homeland.
"ISIL continues to commit gross, systematic abuses of human rights and violations of international law, and in my judgement, ISIL is responsible for genocide against groups in areas under its control (including Yezidis, Christians, and Shia Muslims)," Kerry said.
Kerry said the US was more secure, more respected, and more engaged in the world today than it was when Obama took office eight years ago.
"We have brought the international community together to confront the most serious challenges we face and to seize the most significant opportunities that will shape our future," he said.
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