An AFP correspondent accompanying the Israeli premier said Netanyahu arrived in Moscow in the early afternoon and made no comment to reporters during the flight.
Netanyahu is to meet Putin at the Kremlin at around 1400 GMT to voice his concerns about the deal being hammered out at talks in Geneva.
Tomorrow he will address members of the Russian Jewish community.
Russia is a member of the P5+1 group -- alongside the United States, China, France, Britain and Germany -- which has been struggling to reach a deal to freeze or curb Iran's nuclear activities in exchange for some relief from international sanctions.
The P5+1 are meeting with Iran today in Geneva for talks on the programme, which Israel and the West suspect is aimed at developing a weapons capability but Tehran insists is entirely peaceful.
The last round of talks with Iran that ended on November 10 came tantalisingly close to a framework agreement that supporters say would bolster Iran's new president, a reputed moderate, and buy time for negotiating a comprehensive deal.
Israel's deputy foreign minister, Zeev Elkin, said his country did not expect a radical change in Moscow's stance.
"Russia is not about to espouse the Israeli position," he told public radio ahead of taking off to Russia with Netanyahu. "But any small budge could influence the whole process."
Israel, the region's sole if undeclared nuclear-armed state, has refused to rule out military action to halt Iran's nuclear drive. Washington has also insisted it will strike if necessary to prevent Tehran from developing a nuclear weapon.
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