Patients with symptoms of heart attack or acute myocardial infarction (AMI) account for about 10 per cent of all emergency department consultations, researchers said.
Rapidly identifying AMI, which may be life-threatening, can help initiate treatments in time.
The system allows the timely detection and treatment of alternative causes of acute chest pain - many of which are benign, in which case patients can be reassured and sent home.
The study evaluated the diagnostic performance of the algorithm using pooled data from 4,350 patients, who came to emergency departments with with acute chest pain.
"With this large multicentre analysis using central adjudication we were able to address concerns regarding the suitability of the algorithm for routine clinical care," said Raphael Twerenbold, from the Cardiovascular Research Institute Basel in Switzerland.
"Safety was excellent in the largest ever tested population of patients presenting within the first three hours after chest pain onset," said Twerenbold.
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