New chip to capture live tumour cells in blood

Chinese scientists have developed a new microfluidic chip that can quickly and efficiently segregate and capture live circulating tumour cells (CTCs) from a patient's blood.
The new system captures more than 90 per cent of the CTCs, and can help advance cancer screening methods and treatment assessments.
Tumour cells circulating within a patient's bloodstream can carry cancer from a primary tumour site to distant sites of the body, spreading the disease.
Many currently available devices for detecting CTCs in patients' blood are either too slow for clinical use or have other problems, such as a reduced ability to distinguish between the rare CTCs and more common white blood cells and other non-tumour cells.

The chip can reduce overall processing time, thanks in part to a step in which red blood cells are selectively lysed, or broken apart.
Lysing the red blood cells diminishes the tendency of blood to clog the system, a common problem that slows processing time in similar CTC filtering devices.

The ability to count live, individual CTCs in the bloodstream can help doctors determine the severity of a cancer, since CTC density in the blood is linked to the progression of the disease and patients' likelihood of survival.
The new method could also improve "liquid biopsy" techniques, in which a small amount of blood is drawn as an alternative to conventional tissue biopsies of primary or metastatic tumours.

In addition to potentially improving screening tests, the team believes their approach may someday help doctors control CTC-induced metastasis, which the researchers said can be far more lethal than the original tumour.
"Because our chip is able to capture viable CTCs, it creates opportunities for the development of new and efficient cancer biomarkers," said co-author Ray Han, a professor at Peking University in Beijing.
It also gives researchers a chance to realise what Han called "the grandest dream of all: a technology capable of directly removing CTCs from the human bloodstream - a form of CTC dialysis."
The study was published in the journal Biomicrofluidics, which is produced by American Institute of Physics (AIP) Publishing.