New radiation therapy puts cancer into remission in mice

Scientists have developed a new form of radiation therapy that successfully put cancer into remission in mice, without producing harmful side-effects of conventional chemo and radiation cancer therapies.
Scientists from the University of Missouri found that mice treated with the radiation therapy showed no signs of cancer afterwards.
"Since the 1930s, scientists have sought success with a cancer treatment known as boron neutron capture therapy (BNCT)," said lead researcher Professor M Frederick Hawthorne.
"Our team at MU's International Institute of Nano and Molecular Medicine finally found the way to make BNCT work by taking advantage of a cancer cell's biology with nanochemistry," Hawthorne said.

Cancer cells grow faster than normal cells and in the process absorb more materials than normal cells. Hawthorne's team took advantage of that fact by getting cancer cells to take in and store a boron chemical designed by Hawthorne.
When those boron-infused cancer cells were exposed to neutrons, a subatomic particle, the boron atom shattered and selectively tore apart the cancer cells, sparing neighbouring healthy cells.

The physical properties of boron made Hawthorne's technique possible. A particular form of boron will split when it captures a neutron and release lithium, helium and energy.
Like pool balls careening around a billiards table, the helium and lithium atoms penetrate the cancer cell and destroy it from the inside without harming the surrounding tissues.

"A wide variety of cancers can be attacked with our BNCT technique," Hawthorne said.
"The technique worked excellently in mice. We are ready to move on to trials in larger animals, then people. However, before we can start treating humans, we will need to build suitable equipment and facilities. When it is built, MU will have the first radiation therapy of this kind in the world," Hawthorne said.