PSU Bank, energy, metal, realty and auto sectors pushed the market lower, whereas select technology, media and pharma stocks outperformed.
Weakness in European bourses and mixed trend among Asian peers also weighed on sentiments.
Globally, most European shares were trading lower as investors focused on earnings and monitored President Donald Trump's Asia trip.
The NSE Nifty opened higher at 10,361.95 and moved in a range of 10,384.25 and 10,285.50 before ending at 10,303.15, down 47 points, or 0.45 percent.
Mirroring the frontline indices, the broader market also recorded significant losses with Nifty Midcap and Smallcap indices declining 0.64 per cent and 1.07 per cent, respectively.
Sector-wise, PSU Bank fell 2 per cent, Energy 1.42 per cent, Metal 1.38 per cent, Realty 0.78 per cent, Auto 0.69 per cent, Finance Service 0.58 per cent, Bank 0.46 per cent, Infra 0.45 per cent and Private Bank 0.28 per cent.
IT rose by 0.66 per cent, Pharma 0.27 per cent and Media 0.14 per cent.
Major index gainers were Tech Mahindra, Axis Bank, Asian Paints, Cipla, Sun Pharma, Bharti InfraTel, M&M, Aurobindo Pharma and IndusInd Bank.
The market breadth, indicating the overall health of the market, was in favour of losers. On the NSE, 567 stocks advanced, 1,167 declined and 62 remained unchanged.
Total securities that hit their price bands were 161.
Turnover in the cash segment fell to Rs 35,160.73 crore from Rs 40,573.39 crore on Tuesday.
A total of 15,465.74 lakh shares changed hands in 12,250,403 trades. The market capitalisation of listed firms on NSE stood at Rs 1,41,72,052.42 crore.
Disclaimer: No Business Standard Journalist was involved in creation of this content
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