With Nishikori only just returning from a wrist injury that had sidelined him for five months, Japan's challenge in Morioka will be spearheaded by Yuichi Sugita, who won his first ATP tour singles title in Turkey last summer.
Former champions Italy, making their first visit to Japan, have named world number 22 Fabio Fognini and 46th- ranked Paolo Lorenzi with Andreas Seppi, Thomas Fabbiano and Simone Bolelli also among Corrado Barazzutti's team.
Japan captain Satoshi Iwabuchi has called up world number 100 Taro Daniel alongside the 41st-ranked Sugita in singles, with Go Soeda offering experience alongside Yasutaka Uchiyama and Kiwi-born Ben Mclachlan, who recently reached the Australian Open doubles semi-finals.
But without the former world number four, who has slipped to 28th since injuring his wrist last August, the Japanese will have their work cut out after winning a World Group playoff against Brazil last September.
Italy were champions back in 1976 and have finished runners-up on six occasions.
The Italians won both of their two previous meetings, in Genoa back in 1930 and Milan in 1932. More recently, they lost to Belgium in last year's quarter-finals.
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