"I do not think one test match loss make a difference. We lost the first test and won the second and lost the third. Cricket should not be that fickle. The guys have scored runs and you got to give some time to the guys," Khawaja said.
"Two more tests left and I think it would be more harmful than good when you change teams. I have been in a situation when the Australian team was making a lot of change in chopping during the last five years and it has been more harmful than good.
Australia skipper Clarke is going through a rough patch as he scored 10 and three at Edgbaston, which left him with a meagre series aggregate of 94 runs in six innings.
Asked if Clarke should be changed, Khawaja said: "Michael has been the best player for the last seven years and I think we need his experience in the team.
While Australia suffered a loss to allow England take a 2-1 lead in the Ashes series, Khawaja's men defeated India A by ten wickets with opener Cameron Bancroft scoring 150 in the first innings.
Asked if Bancroft is ready to be promoted to the national squad which is playing the Ashes, Khawaja said: "I do not know. It is the selectors call. Obviously Bancroft batted very well. There is two tests left in the Ashes series. I do not think the selectors want to go too far ahead of themselves.
