"Movement by internally displaced persons continues to be large-scale and fluid, as many Syrians are displaced multiple times," said Jens Laerke, spokesman for the Office of the Coordination of Humanitarian Affairs.
"Over the past months, the number has more than doubled, from an estimated two million to 4.25 million people," he told reporters.
The figures -- combined with more than 1.4 million Syrians who have fled abroad -- mean that more than a quarter of Syria's pre-war population of 22.5 million have been forced to quit their homes since the conflict erupted in March 2011.
Laerke said that despite the risks, aid agencies were still managing to cross the often fluid front-lines to reach those in need.
"Overall, from January to April, some 764,000 people have been reached through UN-led relief convoys to hard-to-access areas," he said.
"Out of 10 convoys which crossed conflict lines, five targeted opposition-controlled areas, while another five went to contested areas."
The United Nations has urged Syria to allow the delivery of aid via Turkey to people in dire need in the north of the country.
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