"More than 2 million adolescents between the ages of 10 and 19 years are living with HIV," marking a 33 per cent rise since 2001, the World Health Organisation said.
"Many do not receive the care and support that they need to stay in good health and prevent transmission. In addition, millions more adolescents are at risk of infection," it warned.
In the world's most AIDS-affected region, sub-Saharan Africa, the majority of adolescents with the virus are girls who have had unprotected sex, sometimes under duress.
In Asia, meanwhile, young drug-users were the worst affected.
The WHO said that the failure to provide proper adolescent-focussed programmes had also resulted in a 50-percent increase in reported AIDS-related deaths in the age group from 2005 to 2012.
In 2005, 70,000 adolescents died of AIDS. Seven years later, the figure was 104,000.
That contrasted starkly with the 30-percent decline in the general population, the WHO underlined.
The year 2005 marked the high point of global AIDS deaths, which hit 2.3 million. Last year, the toll was 1.6 million.
"They face many barriers, including harsh laws, inequalities, stigma and discrimination which prevent them from accessing services that could test, prevent, and treat HIV," McClure added.
"About one-seventh of all new HIV infections occur during adolescence. Unless the barriers are removed, the dream of an AIDS-free generation will never be realised," he insisted.
The data was issued as the WHO released its first adolescent-specific care guidelines ahead of World AIDS Day on December 1.
"Adolescents need health services and support, tailored to their needs. They are less likely than adults to be tested for HIV and often need more support than adults to help them maintain care and to stick to treatment," he added.
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