The shooter was described as a white male in his 50s and he appeared to have died from a self-inflicted wound, local police said in a press conference.
Witnesses said the shooting took place at the Grand 16 theater in the city of Lafayette during a showing of the film "Trainwreck" yesterday.
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Ambulance crews rushed the injured to hospital, Clay Henry from the Acadian Ambulance service told CNN.
Television images showed a hectic scene at the cinema, surrounded by dozens of emergency cars and crews.
"Prayers for Lafayette at Grand Theater. Talking to state police colonel about shooting in Lafayette," tweeted state governor and US presidential candidate Bobby Jindal, who spoke in support of victims and police at a press conference near the scene.
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