The incident occurred at Siruvathur last night.
They said the 45-year-old man suspected his wife's fidelity and allegedly started stabbing her.
Hearing her screams, his three neighbours, including a woman, tried to separate the couple.
However, this made the man more angry and he allegedly stabbed all of them, the police said.
While one person died on the spot, the other three, including his wife, were rushed to a government hospital.
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