"The number of children trapped in humanitarian crisis around the world is both staggering and sobering," the UN children's agency said.
UNICEF said it would need a full USD 2.8 billion (2.6 billion euros) in 2016 to help millions of children in humanitarian emergencies around the world.
The agency said its annual appeal had doubled in just three years as conflicts as well as extreme weather force growing numbers of children from their homes and expose millions more to severe food shortages, violence, disease, abuse and threats to their education.
This is a devastating number. Last year, children living in such areas "were twice as likely to die of mostly preventable causes before they reached the age of five than those in other countries," it said.
UNICEF said the money it was asking for in 2016 would allow it to reach 76 million people - 43 million of them children - across 63 countries.
By far the biggest chunk of that amount - nearly USD 1.2 billion - is needed for aid in war-ravaged Syria and to help the millions of Syrian refugees in neighbouring countries, it said.
UNICEF meanwhile said a full quarter of the aid it wanted to deliver globally was linked to educating children in emergency situations, stressing that it wanted to nearly double the number of children it helps to access education in crisis zones from 4.9 million in 2015 to 8.2 million this year.
"Education is a life-saving intervention in emergencies," UNICEF representative Sikander Khan told reporters in Geneva.
This does not bode well for Syria, where one in four schools have been destroyed and more than two million children are out of school.
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