The incident occurred this evening near Takalabhana village in Shrirampur tehsil, when the state Minister for Home Affairs was on his way from Kopargaon city to Nevasa, Superintendent of Police (SP) Saurabh Tripathi said.
Two of the victims were travelling in a car, which rammed into the minister's escort vehicle carrying police personnel, killing one of the car occupants while injuring the other, the SP said.
Three policemen were also injured in the mishap, he said, adding the injured were admitted to a hospital in Shrirampur by the minister.