With Polio affecting a record 235 people this year in Pakistan, Sharif chaired a Steering Committee meeting on combating the crippling disease in Islamabad.
The meeting was attended by chief minister, senior government official, representatives of World Health Organisation and other international bodies.
Sharif vowed to make the country polio-free in six months, Radio Pakistan reported.
Sharif said the future of children is at stake and his government will not spare any effort to protect them.
The Prime Minister said the federal government, armed forces and civil society stand united in the drive against polio. He said Pakistan shares the concerns of international community on polio, but it should also understand our issues.
Sharif said Pakistan has faced many problems in the anti-polio drive as the frontline health workers have been targeted by the militants.
He said a military operation is successfully underway to flush out the militants.
"We have also seen some breakthroughs in the polio eradication campaign with children of South and North Waziristan are now being immunized," he said.
On this occasion, Japan assured to provide five hundred and fifty million rupees to Pakistan while Bill and Melinda Gates Foundation thirty-seven billion rupees for polio eradication campaign.
The meeting reviewed anti-polio measures and future strategy to eradicate polio from the county.
Polio is still endemic in Pakistan, Afghanistan and Nigeria. The World Health Organisation in May imposed travel restriction on Pakistan.
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