"There are cases in which separation is inevitable," he said during his weekly general audience, with a message hoping to encourage greater compassion in the Church ahead of a highly anticipated global meeting on family life in October.
"Sometimes, it can even be morally necessary, when it's about shielding the weaker spouse or young children from the more serious wounds caused by intimidation and violence, humiliation and exploitation," he said.
Francis said there were many families in "irregular situations" and the question should be how to best help them, and "how to accompany them so that the child does not become daddy or mummy's hostage".
A first synod on the issues last year saw riled conservative bishops mobilise to block the approval of language heralding an unprecedented opening to the gay community and greater flexibility on the treatment of divorced Catholics.
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